Tag Archives: PSK
The Influence of PSP on the Behavior and Growth of the Fetus in Rats
Zheng-de Zhang1, Zhen-bin Qian2, Lan-feng Zhou2 and Bin Xu1 1 Shanghai Institute of Materia Medica, Academia Sinica 2 Department of Toxicology, Shanghai Institute of Labour Health and Occupational Diseases
Abstract
PSP is a new immunomodulating agent prepared and developed by Professor Qing-yao Yang. In the present work its influence on the behavior and growth of fetus in 1st and 2nd generation of rats was investigated.
For behavior study the squirrel wheel test, rotating cylinder test and passive avoidance test were performed, PSP was administered orally at 60, 600 and 6000mg/kg. The results showed that no marked difference in the change of behavior was found between the control and treatment groups. The brain weights of two-generation rats had no marked change either.
For teratogeny test 110 rats were involved PSP was administered orally at 60, 600 and 6000mg/kg in different groups for 10 days. The conditions of the maternal body, embryonic survival and the function and growth of the fetuses were examined. After statistical tests no marked difference was observed in the control and treatment groups.
The data observed showed that PSP has no noticeable toxicity on fetus growth and on the behavioral performance of 1st and 2nd generation rats.
Clinical Experience in the Use of PSP
W.C. Xue and T.F. Liu Cancer Hospital, Shanghai Medical University
There is no really effective treatment for moderate and advanced stages of esophageal carcinoma. Although surgery for the earlier cases has been able to give a 5 years survival rate of 28.7%, such operable cases are relatively few. By far the greater majority are already in stage III to IV when first seen in the clinic, and radiotherapy alone in these cases has given a 5 years survival rate of only 8-14%. In order to improve treatment results, a variety of chemotherapeutic agents have been used in combination surgery, but so far no really effective drug has been found.
The drug PSP (polysaccharide-peptide of Coriolus versicolor) has been discovered and produced by Professor Qing-yao Yang of. It is a new anti-cancer and immuno-regulatory drug, similar to PSK (Krestin) but the effective component has been found to be larger than PSK. Experimental data has proved these properties of PSP, and in vitro as well as in vivo studies have all proved that PSP is superior to PSK. Of course, as is the case with all new drugs, the ultimate proof of its value will have to be shown by clinical application.
Comparsion of Anti-cancer Effect between two kinds of Polysaccharide Peptide of Coriolus versicolor on Human Tumor Cell Lines in Vitro
L.Z. Xu Laboratory of Pathology Cancer Institute, Shanghai Medical University
Abstract
In the present study the anti-cancer effect of polysaccharide peptide of Coriolus versicolor Cov-1 (PSP) was compared with polysaccharide peptide of Coriolus versicolor CM-101 (PSK) on four human tumor cell line targets (SGC 7901, stomach cancer cell; SPC, human lung adenocarcinoma cell; SLY, human monocytic leukemia cell and Mei, human skin histiocytic lymphoma cell) in Vitro.
PSP had similar cytotoxic effects upon human tumor cells as PSK, both inhibiting cell growth. In comparison with control specimens, the SPC cell line treated with PSP (1000ug/ml) for 72 hours at 37oC showed marked morphological changes such as cell swelling, chromatin aggregation, formation of polynuclear cells and sawtooth on the surface of cell nuclei.
PSK as a new immunomodulative drug had been widely used for clinical anticancer therapy in Japan. When combined with chemotherapy, radiotherapy and surgical operation, PSK is found to be able to improve the therapeutic effects. In 1983, a polysaccharide peptide of Coriolus versicolor Cov-1 was isolated from the mycelia by Qing-yao Yang. It is possessed of physio-chemical characteristics similar to PSK and designated as PSP. In the present study the anti-cancer effect of PSP was compared with PSK using four human tumor cell line targets in vitro.
Immune-Boosting Mushroom From Asia Now Available In The U.S.A.
(NAPSI)-The immune system is the body’s ultimate defense against illness and disease. A healthy immune system helps defend the body against the common cold to the most catastrophic illness that you may face.
Boosting your immune system can be easier than you might imagine.
One way is to take supplements and one supplement growing in popularity involves mushrooms. WebMD states that the Coriolus mushroom is used to stimulate the immune system and increase energy.
Traditionally, the Coriolus Versicolor mushroom has been used in China for several thousands of years because of its immune- boosting capabilities.
Its documented usage in history dates back to the mid-1300s during the Ming dynasty. In the 1970s, researchers in Japan started experimenting with the mushroom by extracting its essence in the form of polysaccharide krestin (PSK) and as a polysaccharide peptide (PSP) in China.
Human clinical trials show that the active ingredient in these mushrooms can maintain health and wellness.
There have been over 400 animal and human studies worldwide and in the U.S., including over a dozen human-based placebo trials.
inLife offers Coriolus Versicolor as a daily dietary supplement in pill form to help maintain and stimulate the body’s immune system. It’s available as inForce Immune Builder, a combination of PSK and PSP.
inForce offers much-needed immune-building assistance and it can be taken on a daily basis. inForce is made in the U.S.A. in a cGMP-certified facility and is also vegan friendly.
More information can be found by visiting www.buyinforce.com.
Blastoid transformation of human lymphocytes cultured with protein-bound polysaccharide preparation, PS-K, in vitro.
Ohno R, Yokomaku S, Wakayama K, Sugiura S, Yamada K.
Abstract
The protein-bound polysaccharide preparation, PS-K, isolated from a mushroom, Coriolus versicolor, was found to stimulate human lymphocytes and induce them into blastogenesis in vitro. This stimulatory effect seemed to be nonspecific since lymphocytes from cord blood of newborn babies were also stimulated by PS-K. The highest lymphocyte blastogenesis by PS-K was observed after 5 days in culture.
PMID: 1017585 [PubMed – indexed for MEDLINE]
The effect of a protein-bound polysaccharide from Coriolus versicolor on immunological parameters and experimental infections in mice.
Abstract
The influence of PSK, a protein bound polysaccharide from Coriolus versicolor on various immunological parameters was studied, PSK was found to enhance B cell activity as measured by the spleen plaque-forming cell assay in mice, and to stimulate mouse macrophages as determined by an enhancement of carbon clearance and an increase in the phagocytosis of opsonized sheep red blood cells by peritoneal mouse macrophages in vitro. The activation of mouse macrophages by PSK appeared to correlate with the therapeutic effects of the compound. In mice made granulocytopenic with cyclophosphamide and subsequently infected with a variety of garm-negative pathogens or with Candida albicans, PSK prolonged the average survival time of the animals. The compound also led to a drastic increase in the number of animals surviving such experimental infections as compared to untreated controls. Possible mechanisms responsible for these protective effects by PSK are discussed.
PMID: 6966256 [PubMed – indexed for MEDLINE]
Effect of a protein-bound polysaccharide PS-K on the complement system.
Kato H, Yokoe N, Takemura S, Yoshikawa T, Furukawa Y, Kondo M.
Abstract
A protein-bound polysaccharide from mycelia of Coriolus versicolor PS-K, clinically used as an immunomodulator, has been shown to restore the decreased cellular immune response and to exhibit host-mediated antitumor activity. In this experiment, PS-K was found to increase serum complement level in guinea pig and in human without malignancy, when hemolytic assay of complement was performed using sensitized sheep erythrocytes for the classical pathway activity and unsensitized rabbit erythrocytes for the alternative pathway activity. Assay of complement components revealed increase in C3 level in guinea pig, but no significant changes in C1q, C4, C3, properdin, C3 activator, and C1-inhibitor in human, while C5 and C9 were depressed. Conversion of beta 1C to beta 1A was observed in the 7th day’s plasma of these patients by crossed immunoelectrophoresis. Biosynthesis of guinea pig C3 was accelerated by administration of PS-K, but that of C4 was not affected. These evidences suggested that PS-K might potentiate immune response of the host by elevating serum complement level, in addition to the activation of the complement system.
PMID: 6867480 [PubMed – indexed for MEDLINE]
Krestin (PSK).
Tsukagoshi S, Hashimoto Y, Fujii G, Kobayashi H, Nomoto K, Orita K.
Abstract
A polysaccharide preparation isolated from Coriolus versicolor (Fr.) Quél. of Basidiomycetes (PSK) predominantly consists of glucan and approximately 25% tightly bound protein. PSK was effective against various allogeneic and syngeneic animal tumors and has been given orally to cancer patients. Various suppressed or enhanced immune responses of tumor-bearing animals were restored to normal levels by the administration of PSK in the tumor models tested. The killer T cell activity was augmented in tumor-bearing mice by intraperitoneal or oral administration of PSK, and there was correlation between the PSK associated antitumor effect and the killer T cell activity. It was found that PSK competed with immunosuppressive substances isolated from tumor-bearing mice and that the intestinal immune system appeared to be modulated by oral administration of PSK. After oral administration of 14C- or 35S-labeled PSK to normal rats, it was found that small or large molecular substances appeared in the serum depending on the time elapsed after administration, an indication that large molecular size products were from the digestive tract.
PMID: 6238674 [PubMed – indexed for MEDLINE]
Cloning of sequences induced and suppressed by administration of PSK, antitumor protein-bound polysaccharide.
Hirose K, Hakozaki M, Matsunaga K, Yoshikumi C, Hotta T, Yanagisawa M, Yamamoto M, Endo H.
Abstract
To elucidate the effects of PSK, a protein-bound polysaccharide from Coriolus versicolor, on gene expression in tumor cells, we prepared cDNA clone libraries from PSK-treated and untreated cells of a rat ascites hepatoma line, AH66, which was previously shown to be susceptible to the antitumor action of this compound. Two PSK-induced and one suppressed cDNA clones were selected from these libraries by using a differential colony hybridization and RNA blot hybridization. PSK was thus shown to have a direct effect on the transcription and consequently on the translation of tumor cells.
PMID: 3977892 [PubMed – indexed for MEDLINE]